How should you use this medication?
Take this medication by mouth with a glass of water. Follow the directions on the prescription label. You can take this medication with or without food. Take your medication at the same time each day. Do not take it more often than directed. Do not stop taking except on your care team’s advice. Stopping this medication may increase your risk of a blood clot. Be sure to refill your prescription before you run out of medication. If your care team calls to change your dose, write down the dose and any other instructions. Always read the dose and instructions back to him or her to make sure you understand them. Tell your care team what strength of tablets you have on hand. Ask how many tablets you should take to equal your new dose. Write the date on the new instructions and keep them near your medication. If you are told to stop taking your medication until your next blood test, call your care team if you do not hear anything within 24 hours of the test to find out your new dose or when to restart your prior dose. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.
What are the possible side effects of this medicine?
Side effects that you should report to your care team as soon as possible:
Allergic reactions-skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Bleeding-bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark drown urine, small red or purple spots on skin, unusual bruising or bleeding
Bleeding in the brain-severe headache, stiff neck, confusion, dizziness, change in vision, numbness or weakness of the face, arm or leg, trouble speaking, trouble walking, vomiting
Dark or purple painful toes
Painful swelling, warmth, or redness of the skin, blisters or sores Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
What may interact with this medicine?
Our pharmacists will check to see if this medication will cause any interactions with the information in your profile.
Do not take this medication with any of the following:
Defibrotide This medication may also interact with the following:
Certain antibiotics like erythromycin, clarithromycin, ciprofloxacin, cotrimoxazole, metronidazole, norfloxacin, or tigecycline
Certain antivirals for HIV or hepatitis
Certain medications for blood clots like argatroban, aspirin, bivalirudin, enoxaparin, fondaparinux, heparin, or lepirudin
Certain medications for blood pressure, heart disease, irregular heartbeat
Certain medications for cholesterol like atorvastatin, lovastatin, and simvastatin
Certain medications for depression, anxiety, or psychiatric disorders
Certain medications for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, or voriconazole
Certain medications for seizures like carbamazepine, phenobarbital, phenytoin, rufinamide
Female hormones, including contraceptive or birth control pills
Herbal or dietary products like garlic, ginkgo, ginseng, green tea, kava kava, red yeast rice, St. John’s Wort
NSAIDs, medications for pain and inflammation, like ibuprofen or naproxen
Steroid medications like prednisone or cortisone
Stomach acid blockers like cimetidine, famotidine, ranitidine, or omeprazole