Estradiol (Once Weekly)

How should you use this medication?
This medication is for external use only. Use it as directed on the prescription label. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Do not cut or trim the patch. Do not wear more than 1 patch at a time. Remove the old patch before using a new patch. Use a different site each time to prevent skin irritation. Keep using it unless your care team tells you to stop. This medication comes with INSTRUCTIONS FOR USE. Ask your pharmacist for directions on how to use this medication. Read the information carefully. Talk to your pharmacist or care team if you have questions. A patient package insert for the product will be given with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.

What are the possible side effects of this medicine?
Side effects that you should report to your care team as soon as possible:

Allergic reactions-skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Blood clot-pain, swelling, or warmth in the leg, shortness of breath, chest pain
Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
Gallbladder problems-severe stomach pain, nausea, vomiting, fever
Increase in blood pressure
Liver injury-right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Stroke-sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
Unusual vaginal discharge, itching, or odor
Vaginal bleeding after menopause, pelvic pain Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Bloating
Breast pain or tenderness
Hair loss
Nausea
Stomach pain
Vomiting

What may interact with this medicine?
Our pharmacists will check to see if this medication will cause any interactions with the information in your profile.
Do not take this medication with any of the following:

Aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone This medication may also interact with the following:
Carbamazepine
Certain antibiotics like erythromycin or clarithromycin
Certain antiviral medications for HIV or hepatitis
Certain medications for fungal infections like ketoconazole, itraconazole, or posaconazole
Medications for fungus infections like itraconazole and ketoconazole
Phenobarbital
Raloxifene
Rifampin
St. John’s Wort
Tamoxifen