Estradiol / Norethrindrone Acetate

How should you use this medication?
Take this medicine by mouth with a drink of water. You may take this medicine with food. Follow the directions on the prescription label. You will take one tablet daily at roughly the same time each day. Do not take your medicine more often than directed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What are the possible side effects of this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breast tissue changes or discharge
changes in vision
chest pain
confusion, trouble speaking or understanding
dark urine
general ill feeling or flu-like symptoms
light-colored stools
nausea, vomiting
pain, swelling, warmth in the leg
right upper belly pain
severe headaches
shortness of breath
sudden numbness or weakness of the face, arm or leg
trouble walking, dizziness, loss of balance or coordination
unusual vaginal bleeding
yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

acne
brown spots on the face
change in appetite
change in sexual desire
depressed mood or mood swings
fluid retention and swelling
stomach cramps or bloating
unusually weak or tired
weight gain

What may interact with this medicine?
Our pharmacists will check to see if this medication will cause any interactions with the information in your profile.
Do not take this medicine with any of the following medications:

aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

barbiturates, such as phenobarbital
benzodiazepines
bosentan
bromocriptine
carbamazepine
cimetidine
cyclosporine
dantrolene
grapefruit juice
griseofulvin
hydrocortisone, cortisone, or prednisolone
isoniazid (INH)
medications for diabetes
methotrexate
mineral oil
phenytoin
raloxifene
rifabutin, rifampin, or rifapentine
tamoxifen
thyroid hormones
topiramate
tricyclic antidepressants
warfarin