Duloxetine Delayed Release (DR)

How should you use this medication?
Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Do not crush, cut or chew some capsules of this medication. Some capsules may be opened and sprinkled on applesauce. Check with your care team or pharmacist if you are not sure. You can take this medication with or without food. Take your medication at regular intervals. Do not take your medication more often than directed. Do not stop taking this medication suddenly except upon the advice of your care team. Stopping this medication too quickly may cause serious side effects or your condition may worsen. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team regarding the use of this medication in children. While this medication may be prescribed for children as young as 7 years of age for selected conditions, precautions do apply.

What are the possible side effects of this medicine?
Side effects that you should report to your care team as soon as possible:

Allergic reactions-skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Bleeding-bloody or black, tar-like stools, red or dark brown urine, vomiting blood or brown material that looks like coffee grounds, small, red or purple spots on skin, unusual bleeding or bruising
Increase in blood pressure
Liver injury-right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Low sodium level-muscle weakness, fatigue, dizziness, headache, confusion
Redness, blistering, peeling, or loosening of the skin, including inside the mouth
Serotonin syndrome-irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizures, chills, vomiting, diarrhea
Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
Thoughts of suicide or self-harm, worsening mood, feelings of depression
Trouble passing urine Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Change in sex drive or performance
Constipation
Diarrhea
Dizziness
Dry mouth
Excessive sweating
Loss of appetite
Nausea
Vomiting

What may interact with this medicine?
Our pharmacists will check to see if this medication will cause any interactions with the information in your profile.
Do not take this medication with any of the following:

Desvenlafaxine
Levomilnacipran
Linezolid
MAOIs like Carbex, Eldepryl, Emsam, Marplan, Nardil, and Parnate
Methylene blue (injected into a vein)
Milnacipran
Safinamide
Thioridazine
Venlafaxine
Viloxazine This medication may also interact with the following:
Alcohol
Amphetamines
Aspirin and aspirin-like medications
Certain antibiotics like ciprofloxacin and enoxacin
Certain medications for blood pressure, heart disease, irregular heart beat
Certain medications for depression, anxiety, or psychotic disturbances
Certain medications for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
Certain medications that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
Cimetidine
Fentanyl
Lithium
NSAIDS, medications for pain and inflammation, like ibuprofen or naproxen
Phentermine
Procarbazine
Rasagiline
Sibutramine
St. John’s wort
Theophylline
Tramadol
Tryptophan